Targeting toll-like receptor 7/8 improves host anti-infective response in alcoholic cirrhosis

Toll-like receptor polymorphisms compromise the inflammatory response against bacterial antigen translocation in cirrhosis

Bacterial translocation is associated with clinically relevant complications in cirrhosis. We evaluated the effect of toll-like receptor polymorphisms in the soluble response against these episodes. Consecutive patients with cirrhosis and ascitic fluid were distributed by TLR2 rs4696480, TLR4 rs4986790, and TLR9 rs187084 single-nucleotide polymorphisms. Lipoteichoic acid, lipopolyssaccharide, b...

Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis

BACKGROUND Previously we reported that mice deficient in toll-like receptor 4 (TLR-4) signalling were protected from diet-induced non-alcoholic steatohepatitis (NASH). Another member of the toll-like receptor family, TLR-2, has been shown to play a role in lipid trafficking via uptake of diacylated lipoproteins. However, a role for TLR-2 in NASH has not been elucidated. The objectives of the cu...

Lipopolysaccharide Induced Activation of Toll Like Receptor 4 in Isolated Rat Heart Suggests a Local Immune Response in Myocardium

Background: Myocardial dysfunction is one of the major complications in patients with sepsis where there is a relationship between the blood level of cytokines and the onset of myocardial depression. In many cases of sepsis, the presence of Lipopolysaccharide (LPS) has been established. LPS Binding Protein (LBP) bound endotoxin is recognized by CD14/toll-like receptor-4 (TLR4) complexes in inna...

Targeting Toll-Like Receptor 2 in Ischemia/Reperfusion Injury

Coronary heart disease is an inflammatory disorder of the coronary vessels. With a prevalence of approximately 20% in the general population, it is an endemic problem in industrialized countries. It has been the leading cause of death in the past 80 years or so in the United States. Coronary heart disease may lead to acute coronary syndromes. These cover a wide spectrum of clinical presentation...

Antiviral Response Than Toll-Like Receptor Toll-Like Receptor 3 Mediates a More Potent